Brother's Keeper, a new indie dramedy executive produced by Mark and Jay Duplass, has landed Nick Kroll (The League), Rose Byrne (Insidious: Chapter 2) and Bobby Cannavale (Boardwalk Empire).  Scripted by Jeff Cox and Liz Flahive, the story centers on "a young, narcissistic entrepreneur who crashes and burns on the eve of his company's launch. He leaves Manhattan to move in with his estranged, pregnant sister and his brother-in-law (to be played by real-life item Byrne and Cannavale) and his 3-year-old nephew, only to end up becoming their nanny."  Ross Katz (Taking Chance) will direct the film, which plans on starting production in New York in January. (Via THR)