Amazon Studios has revealed the first teaser trailer for the upcoming drama film Life Itself, written and directed by Dan Fogelman, who’s found great success on the small screen with the hit NBC series This Is Us. The film tells the love story of a couple played by Oscar Isaac and Olivia Wilde, told through multiple generations and spanning both decades and continents. It’s the kind of sweeping, star-studded drama that can either go really well (Magnolia) or really poorly (Collateral Beauty). The key is not delving too deep into the saccharine, and it’s hard to tell from this debut trailer if Life Itself does that or not. Using Band of Horses is almost like cheating—of course whatever imagery you put to “The Funeral” is going to feel emotional.

Fogelman’s early feature credits were for writing family films like Bolt, Tangled, and Cars 2, but he broke out in a big way with 2011’s Crazy, Stupid, Love. After that, he went on to create two semi-successful TV series: The Neighbors and Galavant. But of course it’s This Is Us that really exploded, which kind of feels like the TV equivalent of Crazy, Stupid, Love.—a blend of romance, melodrama, and comedy.

That certainly seems like it could be the same tone for Life Itself, which marks Fogelman’s second film as a director after 2015’s Al Pacino-fronted Danny Collins. Will it be any good? Who knows, but the This Is Us crowd’s interest was no doubt piqued when this trailer debut during last night’s episode.

Check out the Life Itself trailer below. The film also stars Mandy Patinkin, Olivia Cooke, Laia Costa, Annette Bening, and Antonio Banderas. Life Itself opens in theaters on September 21st.

Here’s the official synopsis for Life Itself:

Life Itself centers on a couple (Oscar Isaac and Olivia Wilde) that lead a multi generational love story spanning both decades and continents, from the streets of New York to the Spanish countryside, and are all connected by a single event.