Pajiba reports that Natalie Portman will produce and co-star in Best Buds, a stoner road trip comedy written by actress Jamie Denbo.  The story follows "two best female friends who take a road trip to their friend's wedding in order to save her by bringing her weed."  Pajiba says the comedy is supposed to be in the vein of Harold & Kumar Go to White Castle.  Does this mean Natalie Portman will fuck a giant bag of weed?  Probably not.  It's only in the "vein" of Harold & Kumar.

But Best Buds is another great stride for women in Hollywood and I mean that in all seriousness.  It mirrors the course of American history: women follow men in the right to vote, women follow men in making stoner comedies. This follows an interview Portman did with Elle UK Magazine [via DailyMail] last month where she said the reason she's avoided comedies is that she only gets offered the girlfriend roles.  So if you're looking for yet another reason why Portman is awesome, she's now got three comedies lined up, none of which have her in the girlfriend role: Best Buds, the medieval stoner comedyYour Highness, which hits theaters on October 1st), and the horror-comedy spoofPride and Prejudice and Zombies, which she will also produce through her Handsome Charlie Films banner.

And in case you're questioning her comedy chops, I've included her SNL Digital Short, "Natalie Raps" after the jump.