Ryan Reynolds and director Tarsem (Mirror Mirror) are in talks with Endgame Entertainment and FilmDistrict to make Selfless.  The script by Alex and David Pastor made the 2011 Black List of Hollywood's best unproduced screenplays.  Here's the logline:

An extremely wealthy, elderly man dying from cancer undergoes a radical medical procedure that transfers his consciousness to the body of a healthy young man but everything may not be as good as it seems when he starts to uncover the mystery of the body’s origins and the secret organization that will kill to keep its secrets.

It is certainly a rich premise, one that could lead to a classic mind-bender or quickly go off the rails.  That is doubly true if Reynolds and Tarsem sign on---both have shown flashes of greatness over an uneven filmography.  I know I would like to see them try, so here's hoping the talks pan out.  According to Deadline, James D. Stern, Peter Schlessel, and Ram Bergman will produce (they previously teamed on Looper).