Sam Rockwell is in negotiations with Occupant Films to star in the black comedy/thriller Better Living Through Chemistry. Jeremy Renner, who was previously slated for the role, has jumped ship to maintain a slightly more manageable schedule (he is currently on board Mission: Impossible – Ghost Protocol, The Avengers, and The Bourne Legacy, just to name a few). Starring opposite Jennifer Garner and Michelle Monaghan, Variety reports that Rockwell will play a small town pharmacist whose unhappy marriage (to Monaghan) leaves him vulnerable to the alluring wiles of a sexy trophy wife (Garner) and the highs of prescription drugs. Chaos breaks loose when their affair escalates and the unfaithful couple hatches a plot to murder her husband. The film will be a debut feature from writer-directors Geoff Moore and David Posamentier. Judi Dench is on board to narrate the pic. Hit the jump for more on Rockwell and Better Living Through Chemistry.