Two worlds of superfans are on the verge of collision as Buffy the Vampire Slayer series alums Charisma Carpenter and James Marsters will both guest star in the fifth episode of the seventh season of Supernatural. The episode, titled “Shut Up, Dr. Phil,” will see the two playing husband and wife but obviously with a supernatural twist. Carpenter will play a witch on a rampage after Marsters’ character wrongs her in some way. Showrunner Sera Gamble describes their dynamic rather dramatically to TV Line:

“This episode is Bewitched gone wrong. [It was] all upside for this successful man while he was married to the witch, but now that he’s pissed her off, the whole town is paying the price.”

Sounds like it should be quite a fun reunion for Buffy fans, and a bit of a role reversal for the stars since Marsters played a vampire on the series, while Carpenter played a slayer. The new season of Supernatural starts Friday, September 23rd.

Having finished six seasons and already at work on their seventh, Supernatural is no stranger to Comic-Con, but this year Ballroom 20 would not be enough to hold them. For the first time ever, Supernatural’s panel was hosted in Hall H, with fans filling up the giant hall to scream and cheer for there favorite monster hunting brothers. Moderated by IGN’s Eric Goldman, the panel consisted of writer and showrunner Sera Gamble, writer Ben Edlund, Jensen Ackles (Dean), Jared Padalecki (Sam), Misha Collins (Castiel), Jim Beaver (Bobby Singer), and Mark Sheppard (Crowley).  Hit the jump to read about what is in store for Sam and Dean this year.

Season 6 of The CW drama Supernatural marks not only a new chapter in the show’s story, but also a change in leadership, as executive producer Eric Kripke has handed over show runner duties to Sera Gamble. Having already been on staff as a producer and writer, it’s been a very smooth transition for all involved, and it has helped to invigorate and re-invent the series in a way that will keep it fresh for seasons to come.

During a recent interview to promote the show’s return, Eric Kripke and Sera Gamble talked about wiping the slate clean this season, getting to see how things have affected both Sam (Jared Padalecki) and Dean Winchester (Jensen Ackles) post-apocalypse and how they’re definitely up for more seasons, if there’s the demand for it. Check out what they had to say after the jump: