The first trailer for Vincenzo Natali's sci-fi horror film Splice has gone online.  The film stars Adrien Brody and Sarah Polley as a couple of scientists who don't care about your "rules", man.  Of course, those rules might exist for a reason, as the pair discovers when they secretly splice human DNA with preexisting genetically-engineered experiments.  I'm sure it seemed like a good idea at the time.

It looks like a solid little film and Steve said it was one of the best movies he saw at this year's Sundance Film Festival.  Hit the jump to check out the trailer along with the official synopsis.  Splice hits theaters on June 4th.

Click over to MSN to see the trailer in high resolution.

Here's the official synopsis for Splice:

Elsa (Sarah Polley) and Clive (Adrien Brody), two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.