I want "Splice" to be good.  It's a sci-fi/horror/monster movie, it's produced by Guillermo del Toro, it's directed by Vincenzo Natali ("Cube"), and it stars two awesome actors in the lead roles (Sarah Polley and Adrien Brody).  I don't see how this movie can fail.  Anyway, the first clip has been released and it's after the jump -  along with an introduction by del Toro and Natali.

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To those that are just finding out about "Splice" right now,  here is the film's plot synopsis:

"Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly."

Thanks to Rotten Tomatoes, who scored these two clips for "Splice".  The film still doesn't have an official release date, but we'll keep you updated as we hear it.