Now that The Fighter has become a hit with both audiences and critics alike, it’s safe to say director David O. Russell (who recently received a DGA award nomination) has his choice of projects. Having already jumped on board to write and direct the film adaptation of the popular Uncharted video game series, Russell is also in talks to team up with actor-comedian Vince Vaughn. The duo are attempting to adapt Boom! Studios’ comic book 2 Guns for the big screen.Universal Pictures originally positioned the adaptation as a starring vehicle for Vaughn and his Wedding Crashers co-star Owen Wilson with a script written by TV writer Blake Masters (Brotherhood). Russell will rewrite Masters’ script, and is considering tackling the project before heading into Uncharted territory. The 2 Guns comic was written by Steven Grant with art by Mat Santolouco. Hit the jump for more.Here’s the plot synopsis for 2 Guns according to Heat Vision:

A DEA agent and an undercover Naval Intelligence officer are unwittingly investigating each other and who steal mob money for the good guys. They realize later that the mob actually got them to steal $50 million from the CIA.

Russell and Vaughn were previously linked to Old St. Louis, but that it's unclear where that project stands now. Since then Russell has been linked to various projects, including Under Cover with Jim Carrey and an untitled Ice Cube-starring Dirty Harry-esque crime drama, so I’ll remain skeptical until I hear some solid details regarding his involvement. However, 2 Guns sounds like a nice Three Kings-ish picture for the director -- a comedy that mixes both action and intellect. Vaughn would do wonders with a Russell-penned screenplay, what with his rapid-fire delivery and deft comic timing. Personally, I hope this happens -- in Russell I trust.

Here's the official description for 2 Guns:

A pulp story about cops and thieves and the men that are something in between. Trench has targeted a local bank to rob, and asked Steadman in on the job. Trench figures it's a great way to score -- considering it's a cover for mob money. They'll be thieves ripping off thieves. But what Steadman doesn't know is that Trench is a DEA agent. And what Trench doesn't know is that Steadman's a Naval Intelligence officer. They're both cops! And neither one knows that they're not robbing the mob, they've been set up to steal $50 million from the CIA! A light-hearted crime romp in the vein of Ocean's Thirteen and The Italian Job from comics legend, Steven Grant! [Boom! Studios]