The film centers on a compromised shipment of cocaine and the journey to take it through international borders. When a drug cartel honcho, known only as The Boss (Barry Pepper). enlists his two most trusted partners -- a henchman called The Cook (Nicolas Cage) and a trafficker called The man (Laurence Fishburne) -- to get the drugs to their destination safely, the duo head out on a dangerous mission while being tracked down by Federal Agents.

Running with the Devil also stars Adam Goldberg, Leslie Bibb, Clifton Collins Jr., Peter Facinelli, Christian Tappan, Natalia Reyes and Cole Hauser. Written and directed by Jason Cabell, the film arrives in theaters and On Demand/digital on September 20. Watch our exclusive trailer premiere below followed by a new poster debut.

Here's the official synopsis:

When a cocaine shipment is compromised to the dismay of a drug cartel’s CEO, known simply as The Boss, he orders his most trusted henchman, The Cook, and his partner, another master drug trafficker known as The Man, on a dangerous journey to audit the company’s supply chain. As the drugs make their perilous trek across international borders, past gangsters, refiners, and couriers, they are also being tracked by Federal Agents. When The Cook realizes where the network is breaking down, it may be too late to keep the cartel satisfied.