Now that Family Guy creator Seth MacFarlane is putting the finishing touches on his second directorial feature, A Million Ways to Die in the West, he’s starting to put the pieces together for the Ted sequel—and a casting shakeup is in the works.  Deadline reports that Amanda Seyfried is set to play the female lead in Ted 2, with Mila Kunis only expected to reprise her role as Lori in a “tiny appearance”, if at all.  This is due to a creative decision on behalf of MacFarlane and co-writers Alec Sulkin and Wellesley Wild and not some falling out between MacFarlane and Kunis, so it sounds like Mark Wahlberg’s John will likely be getting a new love interest in the follow-up.

Though Seyfried has been doing more dramatic or genre-oriented work in the past few years, fans of Mean Girls will remember she’s also a pretty skilled comedic actress.  She also has a supporting role in A Million Ways to Die in the West, so she and MacFarlane already have a rapport.  Ted 2 is slated for release on June 26, 2015, while A Million Ways opens this May.